No, our products are not synthetic estrogens. Our powders are derived from all natural non-gmo Wild Yam. However, our products do not contain wild yam as we only extract the sterols from the plant. Our creams do not contain Soy. Should Estro-Life and Progesto-Life be applied in the morning or at night? We recommend that Estro-Life be applied in the morning and Progesto-Life be applied at night. This will also avoid application issues between the two creams if they are being used together, as we recommend.